Journal article
Unraveling the roles of PLIN5: Linking cell biology to physiology
RR Mason, MJ Watt
Trends in Endocrinology and Metabolism | ELSEVIER SCIENCE LONDON | Published : 2015
Abstract
The discovery of perilipin (PLIN) 1 provided a major conceptual shift in the understanding of adipose tissue lipolysis and generated intense interest in lipid droplet biology research. The subsequent discovery of other PLIN proteins revealed unique tissue distribution profiles, subcellular locations, and lipid-binding properties and divergent cellular functions. PLIN5 is highly expressed in oxidative tissues such as skeletal muscle, liver, and heart and is central to lipid homeostasis in these tissues. Studies in cell systems have ascribed several metabolic roles to PLIN5 and demonstrated interactions with other proteins that are requisite for these functions. We examine recent in vivo studi..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors thank Dr Renea Taylor (Monash University) for critical reading of the manuscript. M.J.W. is supported by the National Health and Medical Research Council of Australia (1077703 and 1047138) and R.R.M. by a Paul McNamee Postgraduate award co-funded by the Faculty of Medicine, Nursing, and Health Sciences of Monash University and Monash Sport.